MES1 — Aspergillus nidulans FGSC A4

Summary

AnMES1 (ANIA_01380) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a methionine—tRNA ligase (EC 6.1.1.10) with methionine-tRNA ligase activity, sequence-specific mRNA binding, tRNA binding, and ATP binding. The protein belongs to the MetRS_Zn and Met-tRNA_ligase_1 domain families and localises to the cytosol, mitochondria, mitochondrial lumen, stress granules, and multisynthetase complexes. It is associated with methionyl-tRNA aminoacylation, cytoplasmic and mitochondrial translation, asexual reproduction, mating, morphogenesis, and endocytosis. Phenotypic associations link AnMES1 to increased cell size, G1 cell-cycle arrest, abnormal pseudohyphal and filamentous growth, decreased sporulation and viability, altered stress resistance (including increased thermotolerance and cold sensitivity), reduced telomere length, increased transposable element transposition, and decreased silencing.