PGK — Aspergillus nidulans FGSC A4

Summary

AnPGK (ANIA_01246) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a phosphoglycerate kinase (EC 2.7.2.3), an enzyme with phosphoglycerate kinase activity that binds ADP, ATP and metals. It is associated with glycolytic process, gluconeogenesis, negative regulation of pyruvate decarboxylation to acetyl-CoA, secondary metabolism, and homeostasis. The protein localises to both mitochondria and cytosol. AnPGK is linked to respiration rate and a wide array of phenotypes including altered cell cycle progression, decreased cell death, abnormal replicative lifespan, increased adhesion and mating efficiency, delayed autophagy, sterile mating, and abnormal prion inheritance and colony morphology. Studies of related genes in other species connect the family to cell cycle regulation.