PUB1 — Aspergillus nidulans FGSC A4

Summary

AnPUB1 (ANIA_01339) on chromosome 8 encodes a HECT-domain E3 ubiquitin-protein ligase (EC 2.3.2.26) with ubiquitin ligase activity. The gene is associated with protein ubiquitination and ubiquitin-dependent proteolysis, as well as protein localization to the vacuole, vacuolar transport, endocytosis, autophagy, detoxification, secondary metabolism, lipogenesis, and mRNA breakdown. The encoded protein localizes to the cytoplasm. AnPUB1 is associated with numerous phenotypes including abnormal nitrogen utilization, altered cell cycle progression through G2/M, decreased cytokinesis rate, delayed exponential-phase growth, decreased hypoosmotic stress resistance, abnormal Golgi distribution, altered vacuolar and peroxisomal transport, and increased endocytosis. Studies of related genes in other species link the family to additional processes such as cell fusion.