RGLT — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene AnRGLT (symbol RGLT, chromosome 8) encodes a DNA-binding transcription factor with RNA polymerase II-specific activity, belonging to the Zn2Cys6 fungal-type DNA-binding domain superfamily. It is associated with the regulation of gliotoxin and kojic acid anabolism, as well as ubiquinone anabolism, sulfur metabolism, detoxification, secretion, cell death, and immune evasion. The gene product localizes to the nucleus and is linked to positive regulation of transcription by RNA polymerase II. Related genes in other species are associated with reduced virulence and pulmonary aspergillosis, though these associations are not yet established for A. nidulans.