HST4 — Aspergillus nidulans FGSC A4

Summary

ANIA_01226 (HST4, AnHST4) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a sirtuin-family NAD-dependent histone deacetylase, with annotated activity on histones H3K4, H3K9, H3K14, H3K56 and H4K16, and is classified as EC 2.3.1.286. The product also exhibits NAD+ binding, transcription corepressor activity and metal binding. AnHST4 is associated with epigenetic regulation of gene expression, heterochromatin assembly at centromeres, telomeres, rDNA and the mating-type region, and with suppression of telomeric and mitotic recombination. It is linked to regulation of thiamine anabolism, secondary metabolism, cell differentiation, phenotypic switching, fungal-type cell wall biogenesis, and adhesion to and suppression of host immune responses. The protein localises to the nuclear lumen, nucleolus, chromatin and the SET3C complex. Related genes in other species are linked to oxidative stress response and protein content.