PMC1 — Aspergillus nidulans FGSC A4

Summary

ANIA_01189 (symbol PMC1, preferred name AnPMC1) on Aspergillus nidulans chromosome 8 encodes a P-type ATPase of the IIB subfamily with potassium:proton transporter activity, K+-transporting ATPase activity, and additional cation transporter activities including sodium, manganese, and calcium. The gene is associated with multiple ion transport processes—potassium, sodium, calcium, and manganese membrane transport—as well as cellular ion homeostasis, cell pH reduction, folate biosynthesis, and the unfolded protein response. The encoded protein localises to the plasma membrane, vacuolar membrane, Golgi membrane, ER membrane, and nuclear envelope. AnPMC1 is linked to calcium sensitivity and a wide range of phenotypes including abnormal Golgi distribution and morphology, absent spore germination, altered endocytosis and vacuolar transport, increased ionic stress resistance, and decreased necrotic cell death. Related genes in other species are linked to reduced virulence.