PMT3 — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene PMT3 (also known as sumO or SMT3) on chromosome 8 encodes a protein with a Rad60/SUMO-like domain and a ubiquitin-like domain. As a protein tag, it is associated with E3 protein ligase binding and is linked to sumoylation and desumoylation. The gene is associated with cell cycle progression through interphase, metaphase, anaphase, and telophase, as well as mitotic recombination-dependent replication fork processing and telomere maintenance. It is also associated with secondary metabolism, specifically the anabolism of sterigmatocystin, austinol, and dehydroaustinol, and with asperthecin metabolism and formation. Localization evidence links the product to the nucleus, nucleoplasm, mitotic spindle pole body, septin ring, and linear element. Phenotypic associations include effects on asexual sporulation, chromosome segregation, meiosis, and resistance to chemicals. Studies of related genes in other species link the family to reduced virulence.