AMT1 — Aspergillus nidulans FGSC A4

Summary

ANIA_01181, also known as AMT1, encodes a protein with ammonium channel activity and methylammonium transmembrane transporter activity, belonging to the ammonium/urea transporter family. In Aspergillus nidulans, the gene is associated with ammonium import across the plasma membrane, ammonium membrane transport, and nitrogen utilization. The encoded protein localizes to the plasma membrane, fungal-type vacuole, and Golgi complex. The gene is associated with numerous phenotypes including abnormal biofilm formation, increased sporulation, increased virulence, decreased nitrogen source utilization, abnormal plasma membrane morphology, increased necrotic cell death, and altered cell cycle progression. Additional associations include abnormal autophagy, increased pexophagy, decreased mitochondrial transport, and increased entry into G0 stationary phase. Related genes in other species link the family to protein content, phosphate content, and acid sensitivity traits.