BML — Aspergillus nidulans FGSC A4

Summary

ANIA_01182 (symbol BML, also known as AnBML, TUB2, AnNDA3, NDA3, AnTUB2) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a beta-tubulin protein (benA, CBF87981) that is a structural constituent of the cytoskeleton, possesses GTPase activity, binds GTP and metal ions, and localises to microtubules, the spindle microtubule, cytoplasmic microtubule, tubulin complex and cytoplasm. The gene is associated with supramolecular fiber organisation, microtubule-based processes, nuclear migration along microtubules, microtubule shortening, mitotic spindle breakdown and organisation, mitotic chromosome segregation, the mitotic cell cycle, and response to antibiotic. Phenotypic associations include abnormal colony size, altered cell cycle progression (delayed or increased duration in anaphase, metaphase, S phase), premature or arrested meiosis, absent apoptosis, delayed autophagy, abnormal nuclear fusion during mating, increased polyploidy and aneuploidy, decreased chromosome segregation, and abnormal RNA modification and silencing. Related genes in other species link it to resistance to chemicals, cold sensitivity, and altered virulence.