DUG3 — Aspergillus nidulans FGSC A4

Summary

ANIA_01092 (symbol DUG3) in Aspergillus nidulans FGSC A4 encodes a glutamine amidotransferase with omega peptidase and glutathione hydrolase activities, belonging to the EgtC-like and gamma-glutamyl amide hydrolase families. The gene is associated with glutathione breakdown, protein secretion, mycotoxin and sterigmatocystin anabolism, and homeostasis, and its product localizes to the cytoplasm. Phenotypic associations include abnormal nutrient utilization, decreased sulfur source utilization, increased UV and metal resistance, altered colony appearance, increased chemical compound excretion, altered replicative and chronological lifespan, decreased innate thermotolerance, altered heat sensitivity, altered oxidative stress resistance, altered protein/peptide accumulation, altered toxin resistance, altered chemical compound accumulation, altered competitive fitness, decreased vegetative growth rate, and auxotrophy. Studies of related genes in other species link the family to decreased hyperosmotic stress resistance and abnormal vacuolar morphology.