TRS130 — Aspergillus nidulans FGSC A4

Summary

ANIA_01038 (symbol TRS130, AnTRS130) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a putative TMEM1 family protein containing TRAPPC10/Trs130 domains. The gene is associated with PGE to Golgi transport and intra-Golgi transport, and its product localises to the cytosol. AnTRS130 is associated with decreased autophagy rate, decreased pexophagy rate, decreased cell cycle progression, absent cell cycle progression, abnormal nucleophagy, absent late nucleophagy, abnormal Golgi morphology, decreased cell death, increased nutrient uptake, abnormal endocytosis, decreased meiosis, abnormal protein secretion, decreased prion loss, absent filamentous growth, absent protein secretion, decreased colony size, increased mitochondrial rho- mutation frequency, absent mitophagy, abnormal cell cycle progression in S phase, absent pexophagy, abnormal cytoskeleton morphology, decreased protein transport, abnormal vacuolar transport, abnormal redox state, decreased vacuolar transport, absent cell death, absent autophagy, abnormal subcellular morphology, decreased small molecule transport, and decreased protein secretion. Related genes in other species link the family to the TRAPPII protein complex.