HOG1 — Aspergillus nidulans FGSC A4

Summary

ANIA_01017 (HOG1/hogA) on chromosome 8 encodes a mitogen-activated protein kinase (MAPK) with serine/threonine kinase activity (EC 2.7.11.24) and ATP binding. In Aspergillus nidulans, this gene is associated with the stress-activated MAPK cascade, osmolarity sensing, the HOG response, conidiophore development, asexual reproduction, germ tube formation, quorum sensing, mitochondrial fission, carbohydrate utilization, and reductive iron assimilation. It localizes to both the cytoplasm and nucleus. The gene is linked to turgor pressure, osmotic stress resistance, cell cycle progression, nuclear import/export, mating efficiency, flocculation, acquired thermotolerance, and nutrient uptake. Studies of related genes in other species connect the family to virulence, germination rate, and responses to salt, oxidative stress, and acid.