NIIA — Aspergillus nidulans FGSC A4

Summary

ANIA_01007 (symbol NIIA, niiA) on Aspergillus nidulans chromosome 8 encodes a nitrite reductase (NADPH) (EC 1.7.1.4) with NADP, FAD, heme, and 2Fe-2S and 4Fe-4S cluster binding activities, placing it in the NasD-like and Rieske-like NirD families. The gene is associated with nitrate assimilation, nitrate import, and nitrate uptake, as well as responses to hypoxia, anaerobic respiration, asexual sporulation, hyphal growth, and secondary metabolism including aflatoxin biosynthesis. Additional links to meiotic gene conversion, nuclear division, mitosis, ATP and heme anabolism, sphingolipid metabolism, and digestion have been noted. Related genes in other species support the family’s conserved role in nitrate reduction.