NIAD — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene NIAD (ANIA_01006) on chromosome 8 encodes a nitrate reductase (NADPH) (EC 1.7.1.3), a molybdenum cofactor- and heme-binding oxidoreductase with cytochrome-b5 reductase and FAD-binding domains. This enzyme is associated with nitrate assimilation and nitrate import, as well as with nitrogen utilization, anaerobic respiration, response to hypoxia, and nitric oxide anabolism. The gene product has been linked to molybdenum content and nitrate uptake. It is also connected to processes including arginine breakdown, gibberellin biosynthesis, DNA-mediated transformation, and regulation of mRNA stability. Localization evidence associates the protein with the mitochondrial outer membrane, endoplasmic reticulum, and plasma membrane. Studies of related genes in other species link the family to nitrate transport.