pyrG — Aspergillus nidulans FGSC A4

Summary

ANIA_00919 (pyrG) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes an uncharacterized protein with an aldolase TIM domain and possesses both orotidine-5'-phosphate decarboxylase and orotate phosphoribosyltransferase activities. The gene is associated with de novo UMP biosynthesis, de novo pyrimidine base anabolism, DNA integration, homologous recombination, mitosis, nuclear division, asexual sporulation, regeneration, pigment anabolism, melanin anabolism, and aflatoxin anabolism. The encoded product localises to the cytosol. Related genes in other species connect the family to orotidine 5'-phosphate decarboxylase activity (EC 4.1.1.23).