OS-5 — Aspergillus nidulans FGSC A4

Summary

ANIA_00931 (OS-5, pbsA) on Aspergillus nidulans chromosome 8 encodes a dual-specificity protein kinase with MAPKK activity (EC 2.7.12.2) and Nalpha-acetyltransferase activity, belonging to the Ser/Thr kinase family. The gene is associated with multiple MAPK cascades including the cell integrity, pheromone response, p38, and osmosensory Sho1 pathways, as well as carbon catabolite repression, filamentous growth, ascospore formation, and positive regulation of appressorium formation. It localizes to the NatB complex, Mcs4 RR-MAPKKK complex, cell tips, bud neck, and division septum. Phenotypic associations include increased sporulation and fermentative growth, altered carbon utilization, increased thermotolerance, absent apoptosis, and abnormal colony color. Related genes in other species are linked to virulence, pathogenicity, and stress responses including salt, acid, and oxidative stress tolerance.