CAP1 — Aspergillus nidulans FGSC A4

Summary

AnCAP1 (CAP1) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes an adenylyl cyclase-associated protein (CAP) containing CAP_N and CAP_C domains. The product binds adenylyl cyclase, actin, and identical proteins. It is associated with actin filament destabilization, depolymerization, and severing, as well as regulation of actin polymerization and organization. AnCAP1 is linked to Ras protein signal transduction, the glucose-sensing PKA pathway, endocytic recycling, endocytosis, hyphal growth, and positive regulation of mitochondrial fission. It localizes to the growing cell tip, division septum, cross wall, actin patch, and cytoplasm. Phenotypic associations include abnormal filamentous growth, absent spore germination, sterility, abnormal endocytosis, increased pexophagy, decreased nucleophagy, abnormal prion inheritance and formation, absent innate thermotolerance, and altered pheromone sensitivity and production. Studies of related genes in other species link the family to oxidative stress response and acid sensitivity.