PSD1 — Aspergillus nidulans FGSC A4

Summary

AnPSD1 (ANIA_00910) on chromosome 8 of Aspergillus nidulans encodes a phosphatidylserine decarboxylase (EC 4.1.1.65), a member of the PSD_type1_euk family. The enzyme is associated with phosphatidylethanolamine, phosphatidylserine, and phosphatidylcholine anabolism, as well as protein autoprocessing, mitochondrial electron transport, and positive regulation of mitochondrial fusion and protein processing. It localises to the mitochondrial inner membrane, ER membrane, nuclear envelope, and adiposomes. The gene is linked to filamentous growth, biofilm formation, cellular responses to starvation, neutral pH, and biotic stimuli, and to lipid raft localisation and methylation. Annotated associations include decreased oxidative phosphorylation, abnormal filamentous growth and septum formation, absent spore germination, increased apoptosis, decreased lifespan, and increased ionic stress resistance. Studies of related genes in other species connect the family to mitochondrial transport, autophagy, and vacuolar transport.