AMD2 — Aspergillus nidulans FGSC A4

Summary

AnAMD2 (ANIA_00828) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a protein with amidase activity and glutaminyl-tRNA synthase (glutamine-hydrolyzing) activity, belonging to the amidase domain family. The gene is associated with glutaminyl-tRNAGln biosynthesis via transamidation, mitochondrial translation, carbon catabolite repression, catabolite repression, and antibiotic anabolism. Its product localizes to the glutamyl-tRNA(Gln) amidotransferase complex and mitochondria. Studies of related genes in other species link the family to EC 6.3.5.7 and EC 3.5.1.4 activities, as well as to altered competitive fitness, starvation resistance, and chemical resistance phenotypes.