HSP98 — Aspergillus nidulans FGSC A4

Summary

ANIA_00858 (HSP98) on Aspergillus nidulans chromosome 8 encodes a heat shock protein with ATP-dependent protein disaggregase activity, misfolded protein binding, and ATP hydrolase activity, belonging to the ClpB/ClpA AAA+ ATPase family. The gene is associated with cellular response to heat and misfolded proteins, protein refolding and stabilization, cellular thermotolerance, and stress response. It is linked to microtubule-based transport, protein unfolding and breakdown, homeostasis, and biosynthesis of mycose, glucan, and chitin. Associations with conidia and ascospore formation have also been observed. The encoded protein localizes to the cytoplasm, nucleus, nuclear envelope, mitochondrial lumen, and protein aggregate centers. Phenotypic associations include abnormal nitrogen source utilization, increased prion inheritance, and altered chemical compound excretion, while vegetative growth rate and acquired thermotolerance appear normal.