lamA — Aspergillus nidulans FGSC A4

Summary

ANIA_00887 (lamA) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a protein with biotin carboxylase, acetyl-CoA carboxylase, pyruvate carboxylase, urea carboxylase, and allophanate hydrolase activities (EC 6.3.4.6). The protein contains multiple biotin-binding and ATP-grasp domains. It is associated with malonyl-CoA and fatty acid biosynthesis, urea breakdown, gluconeogenesis, generation of precursor metabolites and energy, DNA-mediated transformation, mitotic nuclear membrane biogenesis, and regulation of gene expression. The product localises to mitochondria, cytoplasm, and cytosol. Studies of related genes in other species link the family to additional carboxylase and hydrolase activities (EC 6.4.1.1, 6.4.1.2, 6.3.4.14, 3.5.1.54) and to Fusarium pathogens, though these associations are not established for A. nidulans itself.