LEU3 — Aspergillus nidulans FGSC A4

Summary

ANIA_00840 (AnLEU3) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a 2-isopropylmalate synthase (EC 2.3.3.13). The gene is annotated to L-leucine anabolism, valine anabolism, and amino acid anabolism, as well as to siderophore metabolism, proteolysis, autophagy, and homeostasis. The product localises to the mitochondrial lumen and mitochondria. Associations with cell cycle progression, budding patterns, pseudohyphal growth, fermentative metabolism, and stress responses (osmotic, acid pH, thermotolerance) have been reported, along with effects on prion inheritance and nuclear export. Related genes in other species are linked to loss of pathogenicity and reduced virulence, and the gene has been connected to pulmonary aspergillosis in model systems.