HIS2 — Aspergillus nidulans FGSC A4

Summary

AnHIS2 (ANIA_00797) on chromosome 8 encodes a trifunctional histidine biosynthesis enzyme with phosphoribosyl-ATP diphosphatase (EC 3.5.4.19), phosphoribosyl-AMP cyclohydrolase (EC 3.6.1.31) and histidinol dehydrogenase (EC 1.1.1.23) activities, and binds NAD, ATP and metal ions. The gene is associated with histidine anabolism, nicotinate breakdown, asexual reproduction, cellular response to farnesol, and cytoplasmic localisation. AnHIS2 is linked to abnormal mitochondrial transport and genome maintenance, decreased pexophagy and reticulophagy, altered cell cycle progression (S phase arrest, G2/M arrest), abnormal chromosome segregation, budding and endomembrane morphology, increased pseudohyphal growth, decreased osmotic stress resistance and acquired thermotolerance, and altered sporulation efficiency. Related genes in other species are linked to heat sensitivity.