gal4 — Aspergillus nidulans FGSC A4

Summary

ANIA_00742, also known as gal4, encodes a Zn(II)2Cys6 transcription factor on Aspergillus nidulans chromosome 8. The protein possesses DNA-binding transcription activator activity specific to RNA polymerase II and sequence-specific DNA binding. This gene is associated with positive regulation of thiamin biosynthetic process, RNA-dependent gene silencing, and upregulation of transcription by galactose. It is also linked to nitrate assimilation, aflatoxin and sterigmatocystin anabolism, and positive regulation of metabolism. The product localizes to the nucleus, cytoplasm, and membrane. Related genes in other species are linked to reduced virulence and pulmonary aspergillosis.