TRP1 — Aspergillus nidulans FGSC A4

Summary

ANIA_00648 (TRP1, trpC) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a protein with phosphoribosylanthranilate isomerase, indole-3-glycerol-phosphate synthase, and anthranilate synthase activities, and contains indole-3-glycerol-phosphate synthase and PRAI domains. The gene is associated with tryptophan formation, indole and alkaloid anabolism, and amino acid anabolism. It has been linked to conidiophore development, sporulation, appressorium formation, pigmentation, and chitin anabolism, as well as response to salt and calcium signaling. Phenotypic associations include abnormal cell shape, decreased sporulation, absent invasive growth, increased innate thermotolerance, and abnormal protein accumulation. The gene is also associated with DNA-mediated transformation, homologous recombination, and translation initiation. Related genes in other species are linked to oxidative stress response, auxotrophy, and altered vegetative growth.