MAC1 — Aspergillus nidulans FGSC A4
Summary
AnMAC1 (MAC1) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a copper-activated transcription factor containing a copper-fist DNA-binding domain. The product binds copper and zinc, localises to the nucleus, and has RNA polymerase II-specific transcription factor activity. AnMAC1 is associated with cellular copper and iron ion homeostasis, the response to copper, and conidiophore development. Studies of related genes in other species link the family to virulence; for example, sequence-similar genes have been connected to reduced virulence, and the A. fumigatus orthologue is associated with invasive aspergillosis.
Annotations
- Chromosome
- 8
- Related genes
- mac1, MAC1
- GO terms
- DNA-binding Transcription Factor Activity, RNA Polymerase II-specific, Zn binding, Nucleus, DNA-dependent transcription, Positive Regulation Of Transcription By RNA Polymerase II, RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding, DNA binding transcription factor activity, upregulation of transcription, DNA-dependent
- Publications
- PMID:30700512, PMID:19146970, PMID:20023302, PMID:17142568, PMID:9290247, PMID:12955499, PMID:39711596, PMID:28954400
- Traits
- unaffected pathogenicity, reduced virulence