ARP2 — Aspergillus nidulans FGSC A4

Summary

ANIA_00673 (ARP2, AnARP2) on Aspergillus nidulans chromosome 8 encodes an Arp2 homolog, a structural constituent of the cytoskeleton with ATP hydrolase activity and F-actin binding. The gene is associated with actin filament branching, cortical patch organization and assembly, endocytic recycling, hyphal growth, mitochondrial migration and inheritance, ascospore wall assembly, pigmentation, and DNA repair-dependent chromatin remodeling. It localizes to the actin cytoskeleton, actomyosin contractile ring layers, hyphal tip, perinuclear region, and the Ino80, TIP60, and SWR-C complexes. Annotations link ARP2 to the Arp2/3 protein complex and to numerous phenotypes including abnormal cell cycle progression, cytokinesis, filamentous growth, endocytosis, shmoo formation, prion inheritance, and decreased cell fusion and necrotic cell death. Related genes in other species are linked to delayed cytokinesis and abnormal chitin deposition.