RIB1 — Aspergillus nidulans FGSC A4

Summary

ANIA_00670 (symbol RIB1, also known as riboB) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a GTP cyclohydrolase II, an enzyme with cyclohydrolase activity that binds GTP and metal ions, belonging to the RibA-like superfamily. This gene is associated with riboflavin biosynthesis, as well as nuclear division, homologous recombination, and fermentation. It localises to both the cytosol and nucleus. Phenotypic associations link RIB1 to cell cycle progression, including arrest at G1 and G2/M phases, premature metaphase and telophase progression, abnormal cell morphology and size, increased budding and autophagy, decreased sporulation and viability, altered redox state, and increased chitin deposition. Related genes in other species link the family to altered thermotolerance, desiccation resistance, and chronological lifespan.