CDC25 — Aspergillus nidulans FGSC A4

Summary

ANIA_00449 (CDC25) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a Ras guanyl-nucleotide exchange factor (RasGEF) containing a Ras-like GEF domain and a P-loop NTPase domain, with annotated molecular functions including GTPase activity and GTP binding. The gene is associated with protein kinase A activation, cellular response to glucose stimulus, positive regulation of the pheromone response MAPK cascade, regulation of cell division, Ras protein signal transduction, and the adenylate cyclase-activating GPCR signaling pathway. It is linked to traversing the start control point of the mitotic cell cycle, conjugation with cellular fusion, nuclear movement, spindle assembly, nuclear division, cytokinesis, and filamentous growth in response to starvation or biotic stimulus. The encoded product localizes to the plasmalemma, cytosol, and mating projection actin fusion focus.