DLC2 — Aspergillus nidulans FGSC A4

Summary

ANIA_00420 (DLC2, also known as nudG) on chromosome 8 encodes a dynein light chain protein belonging to the DLC_sf family, with dynein intermediate chain binding, plus-end-directed microtubule motor activity, and ATP hydrolase activity. The gene is associated with numerous cellular processes including nuclear migration along microtubules, mitotic and meiotic spindle positioning, septum positioning, asexual and sexual sporulation, conidia formation, mRNA and protein transport, vesicle transport, and NPC assembly. It localizes to the cytoplasmic dynein complex, microtubules, nuclear periphery, cytosol, nucleus, meiotic spindle pole body, and peroxisomal import pore. Phenotypic associations include abnormal nuclear position and import/export, arrested cell cycle progression, absent filamentous growth, abnormal chitin deposition, increased lifespan, and altered redox state. Studies of related genes in other species link them to peroxisomal transport and acid sensitivity.