SAR1 — Aspergillus nidulans FGSC A4

Summary

AnSAR1 (ANIA_00411) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a small GTPase of the SAR1 family, possessing GTPase activity and GTP binding. This gene is associated with , ER-to-Golgi transport, and cisternal maturation, and localises to ER exit sites, , and . AnSAR1 is associated with hyphal growth, morphogenesis, secretion, and the organisation of the Golgi, nuclear envelope, and . Phenotypic associations include abnormal Golgi morphology, altered protein secretion, increased carbon source utilisation, increased lifespan, increased UV resistance, and decreased X-ray resistance. Related genes in other species link the family to COPII vesicle trafficking and ER-to-Golgi transport.