PMA1 — Aspergillus nidulans FGSC A4

Summary

ANIA_00318 (PMA1, AnPMA1) on Aspergillus nidulans chromosome 8 encodes a P-type H⁺-exporting transporter, a plasma membrane ATPase with proton-transporting, potassium-transporting, sodium-transporting, calcium-transporting, and manganese-transporting ATPase activities, as well as ATP hydrolase activity and proton, calcium, and metal binding. The gene is associated with potassium ion export, sodium transport, proton export across the plasma membrane, calcium ion membrane transport and homeostasis, manganese ion transport, cell pH regulation, fermentation, and cephalosporin C anabolism. It localises to the plasma membrane (including cell tips and division sites), lipid rafts, Golgi membrane, fungal-type vacuole, nuclear envelope, and extracellular vesicles. Phenotypic associations include abnormal spore germination, delayed sporulation, altered cell death rate, aberrant plasma membrane morphology, increased nutrient uptake, and absent hyperosmotic stress resistance. Related genes in other species link the family to potassium content and loss of pathogenicity.