DHC1 — Aspergillus nidulans FGSC A4

Summary

ANIA_00118 (DHC1, nudA) on Aspergillus nidulans chromosome 8 encodes a dynein heavy chain, a minus-end-directed microtubule motor ATPase with tubulin, intermediate chain and light intermediate chain binding activities. The gene is associated with nuclear migration along microtubules, organelle and vesicle transport, microtubule dynamics and destabilization, homologous chromosome pairing at meiosis, karyogamy, metula development, septum positioning, and asexual reproduction. The dynein complex localises to astral and cytoplasmic microtubules, the meiotic spindle pole body, hyphal tips and cross walls. Phenotypic associations include delayed or arrested cell cycle progression, abnormal chromosome segregation, increased nuclear size, abnormal mitochondrial transport, abnormal pheromone production and nuclear fusion during mating, increased anaerobic growth, and abnormal lifespan. Studies of related genes in other species link it to spindle positioning and cell cycle regulation.