mdpC — Aspergillus nidulans FGSC A4

Summary

ANIA_00146 (symbol mdpC) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a short-chain dehydrogenase/reductase (SDR family) with tetrahydroxynaphthalene reductase and versicolorin reductase activities, acting on CH-OH group donors (EC 1.3.1.-). The gene is associated with the biosynthesis of multiple secondary metabolites, including melanin, aflatoxin, sterigmatocystin, emodin, monodictyphenone, and abscisic acid. Related genes in other species are linked to tetrahydroxynaphthalene reductase activity (EC 1.1.1.252).