PP2A — Aspergillus nidulans FGSC A4

Summary

ANIA_00164 (AnPP2A, also known as AnPPA3 or PPG1) on Aspergillus nidulans chromosome 8 encodes a protein serine/threonine phosphatase of the PPA2-like family with protein phosphatase activity (EC 3.1.3.16) and metal binding capability. The gene is associated with protein dephosphorylation, negative regulation of mitophagy, regulation of TORC1 signaling, and the septation initiation network (SIN). It has been linked to cell cycle regulation including G1/S transition, negative regulation of mitotic entry, and anaphase cohesion protection, as well as glycogen metabolism and regulation of cytoplasmic translation. The encoded protein localizes to the PP2A complex, mitochondrial outer membrane, mitotic spindle pole body, chromatin, and cytoplasm. Phenotypic associations include abnormal pheromone sensitivity, decreased cell death, increased mitophagy, and altered mitochondrial genome maintenance. Studies of related genes in other species link the family to reduced virulence, acid sensitivity, and disseminated candidiasis.