ATRR — Aspergillus nidulans FGSC A4

Summary

ANIA_00179 (ATRR) on chromosome 8 of Aspergillus nidulans encodes a short-chain dehydrogenase/reductase (SDR) family oxidoreductase with very-long-chain 3-oxoacyl-CoA reductase, ketoreductase, and acylglycerone-phosphate reductase (NADP+) activities, and it binds phosphopantetheine. The gene is associated with fatty acid elongation, phosphatidic acid and ergosterol anabolism, secondary metabolite biosynthesis, biofilm formation, and the cellular response to farnesol. It localises to the ER membrane, cytoplasm, cytosol, and nucleus. ATRR is linked to numerous phenotypes including abnormal cell cycle G2/M progression, decreased acquired thermotolerance, increased telomere length, decreased replicative lifespan, decreased desiccation and UV resistance, decreased vegetative growth and competitive fitness, and altered prion inheritance and toxin resistance. Studies of related genes in other species connect the family to transposable element transposition and chronological lifespan.