AMT1 — Aspergillus nidulans FGSC A4

Summary

ANIA_00209 (AMT1) on chromosome 8 of Aspergillus nidulans encodes a protein with ammonium channel activity and methylammonium transmembrane transporter activity, belonging to the ammonium/urea transporter family. The protein localises to the plasma membrane, fungal-type vacuole, and Golgi complex, and is associated with ammonium and methylammonium membrane transport, including ammonium import across the plasma membrane. AMT1 has been linked to numerous phenotypes, including abnormal biofilm formation, increased sporulation and virulence, decreased nitrogen source utilisation, altered cell cycle progression, abnormal autophagy and pexophagy, increased necrotic cell death, and abnormal respiratory metabolism. It is also connected to decreased rates of small molecule transport and chemical compound accumulation, as well as abnormal plasma membrane morphology and nuclear size. Related genes in other species link the family to protein and phosphate content.