CSC1 — Aspergillus nidulans FGSC A4

Summary

The Aspergillus nidulans gene AnCSC1 (ANIA_00229) on chromosome 8 encodes a DUF221 domain protein with calcium-activated cation channel activity and calcium ion transmembrane transporter activity. It is associated with calcium transport, calcium signaling, amino acid transport, cytokinesis, hyphal growth, and hypersensitivity. The protein localizes to the vacuolar membrane, Golgi membrane, cell tip, cell division site, and plasmalemma. AnCSC1 is linked to cell cycle progression (with premature metaphase and telophase, and arrest at G1, G2/M, and START), abnormal budding patterns, increased chitin deposition, abnormal actin cytoskeleton morphology, altered nutrient utilization (increased carbon source use, absent nitrogen source use), and increased respiratory growth. Studies of related genes in other species link the CSC1/OSCA1-like family to vegetative growth and heat sensitivity.