SRE — Aspergillus nidulans FGSC A4

Summary

ANIA_00176 (SRE, AnSRE) on chromosome 8 encodes a GATA-family transcription factor with iron sensor activity, Fe/S and 2Fe-2S cluster binding, and DNA-binding transcription repressor activity specific to RNA polymerase II. The gene is associated with cellular iron ion homeostasis, including response to iron and iron ion starvation, reductive iron assimilation, iron transport, and regulation of siderophore anabolism and metabolism, specifically downregulation of ferrichrome anabolism and ferricrocin anabolism. It is also linked to ornithine metabolism, heme anabolism, cellular response to copper, NO storage, detoxification, and excretion. The product localises to the nucleus, cytoplasm, and chromatin. Related genes in other species are linked to reduced virulence, oxidative stress response, and polysaccharide content.