GAL4 — Aspergillus nidulans FGSC A4

Summary

ANIA_00022 (GAL4) on Aspergillus nidulans chromosome 8 encodes a melibiase (EC 3.2.1.22), a member of the glycoside hydrolase family 27 that also contains an aldolase TIM barrel domain. The gene is associated with melibiose breakdown, polysaccharide breakdown, and broader carbohydrate metabolism. It is linked to nitrate assimilation, as well as to the anabolism of aflatoxin and sterigmatocystin. The encoded protein is localised to the ER lumen and is also found extracellularly. Studies of related genes in other species link the family to reduced virulence and associations with vascular wilt pathogens such as Verticillium dahliae and Fusarium oxysporum.