sfaD — Aspergillus nidulans FGSC A4

Summary

ANIA_00081 (sfaD) on Aspergillus nidulans chromosome 8 encodes a guanine-nucleotide-binding protein beta subunit (G-protein beta) containing WD40 repeats, with molecular functions including signaling receptor complex adaptor activity, GTP binding, DNA-binding transcription repressor activity, and ubiquitin ligase substrate adaptor activity. The gene is associated with heterotrimeric G-protein complexes, transcription repressor complexes, and SCF complexes. It is associated with negative regulation of conidium formation, positive regulation of sterigmatocystin biosynthesis, carbon catabolite repression, glucose sensing via the PKA pathway, quorum sensing, fruiting body formation, syngamy, and mitigation of host defenses. Additional associations include regulation of fatty acid anabolism, cAMP anabolism, and negative regulation of isoprenoid metabolism and dipeptide transport. Related genes in other species are linked to loss of pathogenicity and reduced virulence.