pkcA — Aspergillus nidulans FGSC A4

Summary

ANIA_00106 (pkcA) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a protein kinase C with novel protein kinase C activity, protein serine/threonine kinase activity, lipid binding, and ATP binding. The gene is associated with regulation of cellular respiration, downregulation of TORC2 signaling, positive regulation of cytoplasmic mRNA processing body assembly, positive regulation of penicillin metabolism, cellular bud neck septin ring organization, regulation of cell shape, regulation of cell wall (1→3)-beta-D-glucan biosynthetic process, and upregulation of conjugation with cellular fusion. The encoded protein localises to the actomyosin contractile ring, cytoskeleton, site of polarized growth, stress granule, division septum, cell cortex of cell tip, cell tip and chromatin. Studies of related genes in other species link the family to germination rate and oxidative stress response.