NCS2 — Aspergillus nidulans FGSC A4

Summary

AnNCS2 (ANIA_00062) on chromosome 8 of Aspergillus nidulans FGSC A4 encodes a protein with a Rossmann-like α/β/α fold that exhibits sulfurtransferase and nucleotidyltransferase activities and binds tRNA. The gene is associated with tRNA thiolation, tRNA wobble uridine modification, protein urmylation, urate transport, and nucleobase transport, and its product localises to the cytosol. AnNCS2 is associated with increased virulence, decreased polyploidy, abnormal aneuploidy, decreased cell cycle progression in S phase, decreased nuclear fusion during mating, absent adhesion, decreased pheromone sensitivity, absent pheromone-induced cell cycle arrest, decreased fermentative growth, premature cell cycle progression in metaphase and telophase, increased budding, decreased respiratory metabolism, abnormal axial budding, absent mating response, decreased protein transport, abnormal cell size and nuclear position, increased bipolar budding, abnormal mitochondrial distribution, increased flocculation, delayed budding, and arrested cell cycle passage through start. Related genes in other species link the family to sporulation, filamentous growth, silencing, carbon source utilisation, and stress resistance.