amdR — Aspergillus nidulans FGSC A4

Summary

ANIA_00026 (symbol amdR) on Aspergillus nidulans chromosome 8 encodes a Zn(II)2Cys6 transcription factor belonging to the Amide_Lactam_Regulators family, with DNA-binding transcription factor activity specific to RNA polymerase II. The gene is associated with carbon catabolite repression, catabolite repression, and positive regulation of transcription by RNA polymerase II. It is linked to penicillin anabolism, fatty acid breakdown, and DNA-mediated transformation, as well as regulation of gene expression and DNA-dependent transcription. The encoded protein localises to the nucleus and binds zinc. Related genes in other species, including Verticillium dahliae and Fusarium oxysporum, are linked by sequence similarity, though these associations are not established for amdR itself.