TRS20 — Aspergillus nidulans FGSC A4

Summary

ANIA_11500 (symbol TRS20, also known as AnTRS20) on chromosome 1 of Aspergillus nidulans FGSC A4 encodes a putative trafficking protein particle complex subunit 2/Sedlin, a member of the Sedlin family and the longin-like domain superfamily. The gene is associated with intra-Golgi transport, ER-to-Golgi transport, macroautophagy, and intracellular protein transport, and its product localizes to the TRAPP complex, cis-Golgi network, endoplasmic reticulum, cytoplasm, and nucleus. AnTRS20 is associated with numerous phenotypes including decreased autophagy and pexophagy, abnormal Golgi morphology, cell cycle progression defects, altered protein secretion and transport, abnormal endocytosis and vacuolar transport, increased telomere length, and increased viability. Related genes in other species connect the family to TRAPPII and TRAPPIII complexes and vesicle trafficking.