CLM2 — Aspergillus nidulans FGSC A4

Summary

AnCLM2 (ANIA_11192) on Aspergillus nidulans chromosome 6 encodes a fungal cytochrome P450 with heme binding, iron binding, and oxidoreductase activity acting on paired donors with oxygen incorporation. The gene is associated with ergosterol, terpenoid, patulin, and secondary metabolite biosynthesis; sexual reproduction; meiosis; lipogenesis; fermentation; endocytosis; autophagy; and hypersensitivity. It localises to the endoplasmic reticulum membrane. Phenotypic associations include decreased micronucleophagy, nucleophagy, and ribophagy; increased cell death and lifespan; arrested vegetative and exponential growth; abnormal cell cycle progression; decreased osmotic stress resistance, iron and phosphorus utilization, and nutrient uptake; and increased fermentative metabolism. Related genes in other species link the family to sterol biosynthesis (ERG11, ERG24, ERG9, ERG28, ERG4) and protein content traits.