pac1 — Aspergillus nidulans FGSC A4

Summary

ANIA_11224 (pac1) on chromosome 2 of Aspergillus nidulans FGSC A4 encodes a putative nucleolar RNase III enzyme with dsRNA-specific RNase activity, RNA hairpin binding, and ribonuclease III activity, and contains dsRBD and RNase III domains. The gene is associated with rRNA processing, U2 and U4 snRNA 3'-end processing, box C/D snoRNA 5'-end processing, termination of RNA polymerase II transcription, nuclear mRNA breakdown, RNA metabolism, and the meiotic cell cycle. It is also linked to microtubule dynamics and localizes to the nucleoplasm, nucleolus, and nucleus. Studies of related genes in other species connect the family to ribonuclease III activity (EC 3.1.26.3).