pyc — Aspergillus nidulans FGSC A4

Summary

ANIA_11009 (pyc) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a putative pyruvate carboxylase with biotin carboxylase, acetyl-CoA carboxylase, pyruvate carboxylase, urea carboxylase, allophanate hydrolase, ligase, and hydrolase activities, and ATP and metal binding. The gene is associated with pyruvate metabolism, gluconeogenesis, fermentation, generation of precursor metabolites and energy, malonyl-CoA and fatty acid anabolism, urea breakdown, and mitotic nuclear membrane biogenesis. The encoded protein localizes to the mitochondria, cytoplasm, and cytosol. Studies of related genes in other species link the family to pyruvate carboxylase (EC 6.4.1.1), acetyl-CoA carboxylase (EC 6.4.1.2), urea carboxylase (EC 6.3.4.6), and allophanate hydrolase (EC 3.5.1.54) activities.