ABCA — Aspergillus nidulans FGSC A4

Summary

ANIA_10949 (ABCA, AnABCA) on Aspergillus nidulans chromosome 4 encodes an ABCG/PDR-type transporter with ATP hydrolase activity and azole ABC transporter activity. The gene is associated with zearalenone biosynthetic process, demethylation, response to toxic substances, and xenobiotic detoxification via transmembrane export across the plasma membrane. It has been linked to vacuolar membrane and plasmalemma localization, as well as associations with homologous recombination and hypersensitivity. Phenotypic associations include abnormal small molecule transport, altered vacuolar distribution and transport, increased sporulation rate, decreased cell death, delayed exit from stationary phase, and abnormal replicative and chronological lifespan. The gene is also associated with nutrient uptake, endocytosis, mitophagy, and cell cycle progression through G1/S phase transition. Studies of related genes in other species link the family to plant height, leaf number, root length, drought tolerance, and reduced virulence.