atrR — Aspergillus nidulans FGSC A4

Summary

ANIA_10961 (atrR) on chromosome 4 of Aspergillus nidulans FGSC A4 encodes a Zn(II)2Cys6 transcription factor with sequence-specific DNA-binding activity, including RNA polymerase II cis-regulatory region binding and transcription factor activity. The gene is associated with positive regulation of transcription by RNA polymerase II, DNA-dependent transcription, and positive regulation of metabolism. It is linked to ergosterol anabolism, biofilm formation, and hypersensitivity. The encoded protein localises to the nucleus, membrane, and cytosol. Studies of related genes in other species connect the atrR family to reduced virulence and pulmonary aspergillosis.